A20 Curtails Primary but Augments Secondary CD8+ T Cell Responses in Intracellular Bacterial Infection
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چکیده
منابع مشابه
A20 Curtails Primary but Augments Secondary CD8+ T Cell Responses in Intracellular Bacterial Infection
The ubiquitin-modifying enzyme A20, an important negative feedback regulator of NF-κB, impairs the expansion of tumor-specific CD8+ T cells but augments the proliferation of autoimmune CD4+ T cells. To study the T cell-specific function of A20 in bacterial infection, we infected T cell-specific A20 knockout (CD4-Cre A20fl/fl) and control mice with Listeria monocytogenes. A20-deficient pathogen-...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep39796